As we are approaching the limits of scalability of conventional complementary metal oxide semicon- ductor technologies, alternative electronic devices are necessary to continue the rapid device minia- turisation we have enjoyed in the 20th century. Molecular electronics aims to miniaturise electronic devices by using subnanometre-scale active components [1]. The potential bene ts of realising this goal include faster peformance, low cost manufacturing and the observation of novel conductance ef- fects [2]. Two techniques commonly used to measure single-molecule conductance, the mechanically controllable break junction (MCBJ) and scanning tunnelling microscope break junction (STM BJ) will be introduced. The construction of the stretching curve and conductance histogram from these measurements will then be discussed. Finally, the key ndings of recent publication from Nature [3], investigating the compression of single molecule conductance using destructive sigma interference, will be outlined.